The association between MTHFR 677C.T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia
نویسندگان
چکیده
Background: Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR 677C.T) may influence risk by modifying DNA methyl-
منابع مشابه
The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia1234
BACKGROUND Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methylation. OBJECTIVE We investigated the associations between MTHFR 677C>T genotype, folate status, and DNA methylation in the colon. DESIGN We conducted a...
متن کاملInvestigating the methylation status of DACT2 gene and its association with MTHFR C677T polymorphism in patients with colorectal cancer
Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...
متن کاملبررسی همبستگی پلی‌مورفیسم ژن MTHFR و سرطان کولورکتال غیر فامیلی
Background and Aim: Colorectal cancer is one of the most common malignancies in worldwide. Because the gene 5, 10-methylene-tetrahydrofolate reductase (MTHFR) plays a key role in methylation, synthesis and repair of DNA, numerous studies have focused on evaluating the correlation between polymorphisms of this gene and sporadic colorectal cancer. This study was carried out to examine the associa...
متن کاملThe association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism, which is an important pathway of the methyl donor for DNA methylation. The MTHFR gene has genetic variants (C667T and A1298C), which cause reduced enzyme activity. Impaired folate metabolism by these genetic variants of MTHFR could change the methylation pattern of DNA including promoter hypermeth...
متن کاملبررسی ارتباط بین آدنومای کولورکتال با غلظت فولات گلبول قرمز و پلی‌مورفیسم ژن آنزیم متیلن تتراهیدروفولات ردوکتاز
Background: Red Blood Cell's (RBC)’s folate may be related to decreased risk of colorectal adenoma. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. The MTHFR C677T polymorphism is located in the Exon 4 region and is associated with the change of folate level. This study evaluated the associations between RBC’s Folate levels and colorectal adenoma ris...
متن کامل